We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy.
- Authors
Yuhua Song; Santai Song; Dong Zhang; Yan Zhang; Liyong Chen; Lu Qian; Ming Shi; Huibin Zhao; Zefei Jiang; Ning Guo
- Abstract
Background: Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significance of Fra-1 expression in breast carcinogenesis. Methods: The expression of Fra-1 was investigated by immunohistochemistry in neoplastic breast diseases ranging from benign fibroadenoma to very aggressive undifferentiated carcinoma. The correlations of Fra-1 expression with other indicators of breast carcinoma prognosis (ER, PR and ErbB2 receptors) were analyzed. Results: All neoplastic breast tissues, either benign or malignant breast tissues, were nuclear immunoreactive for Fra-1-recognizing antibody. The pattern of Fra-1 expression by benign neoplastic cells was predominantly nuclear. However, the nuclear/cytoplasmic concomitant immunoreactivity was observed in all types of breast carcinomas. A clear shift in Fra-1 immunoreactivity, from an exclusively nuclear to a simultaneous nuclear and cytoplasmic localization was noticed in ~90% of breast carcinomas. Conclusion: The overall expression, pattern and intensity of Fra-1 proteins were correlated with breast oncogenesis. Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis.
- Subjects
CYTOPLASM; BREAST cancer; CELL growth; GENE expression; IMMUNOHISTOCHEMISTRY
- Publication
BMC Cancer, 2006, Vol 6, p298
- ISSN
1471-2407
- Publication type
Article
- DOI
10.1186/1471-2407-6-298