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- Title
Voltage-dependent anion channels: the wizard of the mitochondrial outer membrane.
- Authors
Mertins, Barbara; Psakis, Georgios; Essen, Lars-Oliver
- Abstract
Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.
- Subjects
ELECTRIC potential; VOLTAGE dependent capacitors; PROTEINS; METABOLITES; GENETIC regulation
- Publication
Biological Chemistry, 2014, Vol 395, Issue 12, p1435
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2014-0203