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- Title
Simple recipe for accurate T quantification with multi spin-echo acquisitions.
- Authors
Neumann, Daniel; Blaimer, Martin; Jakob, Peter; Breuer, Felix
- Abstract
Objective: The quantification of magnetic resonance relaxation parameters T and T have the potential for improved disease detection and classification over standard clinical weighted imaging. Performing a mono-exponential fit on multi spin-echo (MSE) data provides quantitative T values in a clinically acceptable scan-time. However, due to technical imperfections of refocusing pulses, stimulated echo contributions to the signals lead to significant deviations in the resulting T values. In this work, a simple auto-calibrating correction procedure is presented, allowing the accurate estimation of T from MSE acquisitions. Materials and methods: Correction factors for T values obtained from MSE acquisitions with a mono-exponential fit are derived from simulations following the extended phase graph formulation. A closed formula is given for the calculation of the required correction factors directly from the measured data itself. Results: Simulations and phantom experiments show high accuracy of corrected T values for a wide range of clinically relevant T values and for different nominal refocusing flip angles. In addition, corrected T maps of the human brain are presented. Conclusion: A simple recipe is provided to correct T values obtained from MSE acquisitions via a mono-exponential fit for the influence of stimulated echoes. Since all required parameters are extracted from the data themselves, no additional acquisitions are required.
- Subjects
MAGNETIC resonance imaging of the brain; ELECTRON spin echoes; RADIO frequency; SIGNAL-to-noise ratio; BRAIN imaging
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2014, Vol 27, Issue 6, p567
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-014-0438-3