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- Title
Advances in Anticancer Protein Delivery using Micro-/Nanoparticles.
- Authors
Sun, Wujin; Lu, Yue; Gu, Zhen
- Abstract
Proteins exhibiting anticancer activities, especially those capable of discriminately killing cancer cells, have attracted increasing interest in developing protein-based anticancer therapeutics. This Progress Report surveys recent advances in delivering anticancer proteins directly to tumor tissue for inducing apoptosis/necrosis or indirectly to antigen presenting cells for provoking immune responses. Protein delivery carriers such as inorganic particles, lipid particles, polymeric particles, DNA/protein-based biomacromolecular particles, as well as cell based carriers are reviewed with comments on their advantages and limitations. Future challenges and opportunities are also discussed.
- Subjects
ANTINEOPLASTIC agents; CANCER cells; IMMUNE response; BIOMACROMOLECULES; INORGANIC compounds
- Publication
Particle & Particle Systems Characterization, 2014, Vol 31, Issue 12, p1204
- ISSN
0934-0866
- Publication type
Article
- DOI
10.1002/ppsc.201400140