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- Title
Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish.
- Authors
Lai, Kevin; Amsterdam, Adam; Farrington, Sarah; Bronson, Roderick T.; Hopkins, Nancy; Lees, Jacqueline A.
- Abstract
We have characterized 28 zebrafish lines with heterozygous mutations in ribosomal protein ( rp) genes, and found that 17 of these are prone to develop zebrafish malignant peripheral nerve sheath tumors (zMPNST). Heterozygotes from the vast majority of tumor-prone rp lines were found to be growth-impaired, though not all growth-impaired rp lines were tumor-prone. Significantly, however, the rp lines with the greatest incidence of zMPNSTs all displayed a growth impairment. Furthermore, heterozygous cells from one tumor-prone rp line were out-competed by wild-type cells in chimeric embryos. The growth impairment resulting from heterozygosity for many rp genes suggests that a global defect in protein translation exists in these lines, raising the possibility that a translation defect that precedes tumor development is predictive of tumorigenesis. Developmental Dynamics 238:76-85, 2009. © 2008 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2009, Vol 238, Issue 1, p76
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.21815