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- Title
Synthesis of <sup>13</sup>C‐labelled cutin and suberin monomeric dicarboxylic acids of the general formula HO<sub>2</sub><sup>13</sup>C‐(CH<sub>2</sub>)<sub>n</sub>‐<sup>13</sup>CO<sub>2</sub>H (n = 10, 12, 14, 16, 18, 20, 22, 24, 26, 28)
- Authors
Schink, Carina; Spielvogel, Sandra; Imhof, Wolfgang
- Abstract
13C‐labeled dicarboxylic acids HO213C‐(CH2)n‐13CO2H (n = 10, 12, 14, 16, 18, 20, 22, 24, 26, 28) have been synthesized as internal standards for LC‐MS and GC‐MS analysis of cutin and suberin monomer degradation by soil‐based microorganisms. Different synthetic strategies had to be applied depending on the chain length of the respective synthetic target and because of economic considerations. 13C‐labels were introduced by nucleophilic substitution of a suitable leaving group with labelled potassium cyanide and subsequent hydrolysis of the nitriles to produce the corresponding dicarboxylic acids. All new compounds are characterized by GC/MS, IR, and NMR methods as well as by elemental analysis.
- Subjects
DICARBOXYLIC acids; POTASSIUM cyanide; NITRILES
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2021, Vol 64, Issue 1, p14
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3885