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- Title
Molecular pathway of pancreatic cancer-associated neuropathic pain.
- Authors
Giri, Shweta Subhash; Tripathi, Alok Shiomurti; Erkekoğlu, Pınar; Zaki, Magdi E. A.
- Abstract
The pancreas is a heterocrine gland that has both exocrine and endocrine parts. Most pancreatic cancer begins in the cells that line the ducts of the pancreas and is called pancreatic ductal adenocarcinoma (PDAC). PDAC is the most encountered pancreatic cancer type. One of the most important characteristic features of PDAC is neuropathy which is primarily due to perineural invasion (PNI). PNI develops tumor microenvironment which includes overexpression of fibroblasts cells, macrophages, as well as angiogenesis which can be responsible for neuropathy pain. In tumor microenvironment inactive fibroblasts are converted into an active form that is cancer-associated fibroblasts (CAFs). Neurotrophins they also increase the level of Substance P, calcitonin gene-related peptide which is also involved in pain. Matrix metalloproteases are the zinc-associated proteases enzymes which activates proinflammatory interleukin-1β into its activated form and are responsible for release and activation of Substance P which is responsible for neuropathic pain by transmitting pain signal via dorsal root ganglion. All the molecules and their role in being responsible for neuropathic pain are described below.
- Subjects
NEURALGIA; CALCITONIN gene-related peptide; DORSAL root ganglia; SUBSTANCE P; BRAIN-derived neurotrophic factor; PANCREATIC tumors; NEUROTROPHINS; EXOCRINE pancreatic insufficiency
- Publication
Journal of Biochemical & Molecular Toxicology, 2024, Vol 38, Issue 4, p1
- ISSN
1095-6670
- Publication type
Article
- DOI
10.1002/jbt.23638