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- Title
A Copper-Catalyzed Multicomponent Reaction and 'Click Strategy' for the Stereoselective Synthesis of a New Series of Oxazolone Peptidomimetics with α-Acylamino Amide and β-Amido Ketone Structures.
- Authors
Balan, Biny; Bahulayan, Damodaran
- Abstract
A novel 'click ligation' strategy for the stereoselective synthesis of a medium-size library of structurally complex and functionally diverse oxazolone peptidomimetics, which contain α-acylamino carboxamide or β-amido ketone residues, is presented. Most of these molecules have lipophilicity constant values (log P) in the qualifying range for cell permeability, and that indicates the possibilities of these new molecules to be used in the search for potential inhibitors for a broad spectrum of enzymes.
- Subjects
COPPER research; METALS; OXAZOLONE; OXAZOLES; PEPTIDOMIMETICS
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 12, p2251
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201300057