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- Title
Synthesis of the Major Oxepane Segment of Zoapatanol.
- Authors
Yadav, Jhillu S.; Dash, Uttam; Guguloth, Nagesh; Mohapatra, Debendra K.
- Abstract
A linear synthesis of the major oxepane fragment of zoapatanol, showing the induction of uterine contractions, and cervical dilation and uterine bleeding (by the concentrated zoapatle tea) in early human pregnancy, isolated from the leaves of Mexican zoapatle plant Montanoa tomentosa, is described from known intermediate involving Sharpless asymmetric epoxidation, bis-epoxide opening reaction with CoreyChaykovsky reagent, ring-closing metathesis reaction, and HornerWadsworthEmmons olefination reaction as key steps.
- Subjects
OXEPANES; UTERINE contraction; HEMORRHAGE; MONTANOA; EPOXIDATION
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 4, p663
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201200364