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- Title
Efficient One-Pot Synthesis of Alkyl 2-(Dialkylamino)-4-phenylthiazole-5-carboxylates and Single-Crystal X-Ray Structure of Methyl 2-(Diisopropylamino)-4-phenylthiazole-5-carboxylate.
- Authors
Souldozi, Ali; Ramazani, Ali; Dadrass, Ali Reza; Ślepokura, Katarzyna; Lis, Tadeusz
- Abstract
The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (=dialkyl but-2-ynedioates) in the presence of silica gel (SiO2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5-carboxylates in fairly high yields. The structures of the products were confirmed by their IR, 1H- and 13C-NMR, and mass spectra, and by a single-crystal X-ray structure determination.
- Subjects
AMINES; CARBOXYLATES; THIAZOLES; ORGANOSULFUR compounds; NUCLEAR magnetic resonance
- Publication
Helvetica Chimica Acta, 2012, Vol 95, Issue 2, p339
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201100322