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- Title
Gonadotropin and steroid hormones stimulate proliferation of the rat ovarian surface epithelium.
- Authors
Sherri L. Stewart; Troy D. Querec; Briana N. Gruver; Brendan O'Hare; James S. Babb; Christos Patriotis
- Abstract
The ovarian surface epithelium (OSE) is a single layer of flattened or cuboidal cells covering the ovary. Ninety percent of all human ovarian malignancies arise from this layer of cells. Incessant ovulation, hyperovulation induced by infertility treatment, and hormone replacement therapy have been suggested as risk factors for ovarian cancer. In this study, two groups of rats, with and without surgically induced injury to the ovary, were treated with 17β-estradiol, pregnant mare's serum gonadotropin (PMSG), human chorionic gonadotropin (hCG), or the combination PMSG/hCG, and the proliferative response of the OSE cells was measured using bromodeoxyuridne (BrdU) and 3H-thymidine. All hormones, alone or in combination with ovarian surgery, were found to increase significantly the rate of proliferation of the rat OSE. These data demonstrate that hormones associated with infertility treatments and hormone replacement therapy, as well as injury- or ovulation-induced rupture of the ovarian surface, stimulate the rat OSE, and hence could have a role in the development of ovarian cancer via proliferation-associated mutagenesis, or alternatively, by promoting the rapid selection of OSE cells with accumulated mutations. J. Cell. Physiol. 198: 119124, 2004. © 2003 Wiley-Liss, Inc.
- Subjects
GONADOTROPIN; STEROID hormones; OVARIAN diseases; EPITHELIUM
- Publication
Journal of Cellular Physiology, 2004, Vol 198, Issue 1, p119
- ISSN
0021-9541
- Publication type
Article
- DOI
10.1002/jcp.10401