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- Title
Syntheses of new racemic N<sup>G</sup>-(1-iminoethyl)phosphalysine derivatives as potential inhibitors of nitric oxide synthase.
- Authors
Massa, Mark A.; Pitzele, Barnett S.; Jerome, Gina M.; Moore, William M.; Manning, Pamela T.; Sikorski, James A.
- Abstract
The efficient syntheses of three new racemic NG-(1-iminoethyl)phosphalysine derivatives are reported where the lysine carboxylate group is systematically replaced by phosphonic acid, 4, methyl phosphinic acid, 5, and phosphinic acid, 6. These compounds were evaluated as potential inhibitors of the three isoforms of human nitric oxide synthase. © 2000 John Wiley & Sons, Inc. Heteroatom Chem 11:505-511, 2000
- Publication
Heteroatom Chemistry, 2000, Vol 11, Issue 7, p505
- ISSN
1042-7163
- Publication type
Article
- DOI
10.1002/1098-1071(2000)11:7<505::AID-HC8>3.0.CO;2-V