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- Title
Postchemotherapy PET evaluation correlates with patient outcome in paediatric Hodgkin's disease.
- Authors
Lopci, Egesta; Burnelli, Roberta; Guerra, Luca; Cistaro, Angelina; Piccardo, Arnoldo; Zucchetta, Pietro; Derenzini, Enrico; Todesco, Alessandra; Garaventa, Alberto; Schumacher, Fabio; Farruggia, Piero; Buffardi, Salvatore; Sala, Alessandra; Casale, Fiorina; Indolfi, Paolo; Biondi, Samanta; Pession, Andrea; Fanti, Stefano
- Abstract
Aim: To evaluate the role of postchemotherapy FDG PET and compare it with other predictive factors in paediatric Hodgkin's disease (HD). Materials and methods: In this retrospective study, 98 paediatric patients with HD (enrolled in eight Italian centres) were analysed. Their mean age was 13.8 years (range 5-19 years). A PET scan was performed at the end of chemotherapy and reported as positive or negative on the basis of visual and/or semiquantitative analysis. True outcome was defined as remission or disease on the basis of combined criteria (clinical, instrumental and/or histological) with a mean follow-up period of 25 months. Statistical analyses were performed for the postchemotherapy PET results and other potential predictive factors (age cut-off, stage, presence of bulky masses and therapeutic group) with respect to patient outcome and progression-free survival (PFS). Results: Overall the patients had a mean PFS of 23.5 months (range 4-46 months): 87 achieved remission (88.8%) and 11 showed disease. Of the 98 patients, 17 were positive on postchemotherapy PET . Seven patients (41%) showed disease during follow-up, and relapse occurred in only four out of the 81 patients who were negative on PET ( p = 0.0001). Kaplan-Meier analysis demonstrated significant correlations between PFS and the postchemotherapy PET result ( p = 0.0001) and a cut-off age at diagnosis of 13.3 years ( p = 0.0337), whereas disease stage ( p = 0.7404), therapeutic group ( p = 0.5240) and presence of bulky masses ( p = 0.2208) were not significantly correlated with PFS. Multivariate analysis confirmed a statistically significant correlation with PFS only for the postchemotherapy PET findings ( p = 0.0009). Conclusion: In paediatric HD, age at diagnosis and postchemotherapy PET results are the main predictors of patient outcome and PFS, with FDG PET being the only independent predictive factor for PFS.
- Subjects
ITALY; POSITRON emission tomography; DRUG therapy; HODGKIN'S disease; PEDIATRICS; MULTIVARIATE analysis; PATIENTS
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2011, Vol 38, Issue 9, p1620
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-011-1836-7