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- Title
Zymosan-a Protects the Hematopoietic System from Radiation-Induced Damage by Targeting TLR2 Signaling Pathway.
- Authors
Du, Jicong; Cheng, Ying; Dong, Suhe; Zhang, Pei; Guo, Jiaming; Han, Jiaqi; Gao, Fu; Zhao, Hainan; Sun, Ding; Cui, Jianguo; Cai, Jianming; Liu, Cong
- Abstract
Background/Aims: The hematopoietic system is vulnerable to ionizing radiation and is often severely damaged by radiation. Molecules affecting radioresistance include Toll-like receptor 2. We investigated whether Zymosan-A, a novel TLR2 agonist, can protect the hematopoietic system from radiation-induced damage after total body irradiation. Methods: Mice were exposed to total body radiation after treatment with Zymosan-A or normal saline, and their survival was recorded. Tissue damage was evaluated by hematoxylin-eosin staining. The number of nucleated cells in bone marrow was determined by flow cytometry. Cell viability and apoptosis assay were determined by CCK-8 assay and flow cytometry assay. Enzymelinked immunosorbent assay was used to detect the level of cytokines. Results: Zymosan-A protected mice from radiation-induced death and prevented radiation-induced hematopoietic system damage. Zymosan-A also promoted cell viability and inhibited cell apoptosis caused by radiation, induced radioprotective effects via TLR2, upregulated IL-6, IL-11, IL-12, and TNF-α in vivo. Conclusion: Zymosan-A can provide protection against radiation-induced hematopoietic system damage by targeting the TLR2 signaling pathway. Thus, Zymosan-A can be potentially effective radioprotectant.
- Subjects
ZYMOSAN; HEMATOPOIETIC system; TOLL-like receptors; INTERLEUKIN-6; IONIZING radiation
- Publication
Cellular Physiology & Biochemistry (Karger AG), 2017, Vol 43, Issue 2, p457
- ISSN
1015-8987
- Publication type
Article
- DOI
10.1159/000480472