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- Title
Indirect determination of N-acetyltransferase activity using ammonium metavanadate for evaluating isoniazide excretion with human urine.
- Authors
Garmonov, S. Yu.; Shilova, N. S.; Yakoleva, A. V.; Yusupov, R. A.
- Abstract
Optimum conditions for the analytical determination of isonicotinic acid hydrazide in urine using ammonium metavanadate are established. Anoninvasive method for the indirect determination of N-acetyltransferase activity in human hepatocytes that is based on measurement of the isoniazide fraction excreted with urine for 6 h is proposed.
- Subjects
ISONICOTINIC acid; ACIDS; HYDRAZINES; AMMONIUM; ACETYLTRANSFERASES; ISONIAZID
- Publication
Pharmaceutical Chemistry Journal, 2008, Vol 42, Issue 8, p488
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-008-0157-z