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- Title
Clinical Predictors of Multiple Organ Dysfunction Syndromes in Pediatric patients with Scrub Typhus.
- Authors
Dongying Zhao; Yongjun Zhang; Zhaoqing Yin; Jing Zhao; Defeng Yang; Qun Zhou; Zhao, Dongying; Zhang, Yongjun; Yin, Zhaoqing; Zhao, Jing; Yang, Defeng; Zhou, Qun
- Abstract
Scrub typhus can produce multiple organ dysfunction syndrome (MODS). Early recognition of the patients at risk of MODS would be helpful in providing timely management and reducing the mortality. In all, 449 children with scrub typhus were enrolled at three hospitals in Yunnan, China from January 2010 to January 2015. The patients' clinical status of organ system dysfunction was evaluated on the day of discharge from hospital by using standard criteria. The patients were classified into MODS present (64 cases, 14.3%) or MODS absent (385 cases, 85.7%). Multivariate logistic regression analyses revealed that the prognostic factors for MODS included skin rash (odds ratio, OR = 3.3, p = 0.037), time interval form treatment to defervescence (OR = 1.2, p = 0.035), hemoglobin (OR = 0.54, p = 0.041), platelet counts (OR = 0.06, p < 0.001), aspartate-aminotransferase (OR = 4.7, p = 0.011) and total bilirubin (OR = 2.3, p = 0.013). By describing risk factors resulting in MODS in pediatric scrub typhus, our study provides clinicians with important information to improve the clinical monitoring and prognostication of MODS.
- Subjects
MULTIPLE organ failure; TSUTSUGAMUSHI disease; CHILD mortality; CHILDREN'S health; HOSPITAL admission &; discharge; DISEASE risk factors; GRAM-negative bacteria; GRAM-negative bacterial diseases; HOSPITAL care; MULTIVARIATE analysis; LOGISTIC regression analysis; RESIDENTIAL patterns; TREATMENT effectiveness; DISEASE complications; DIAGNOSIS
- Publication
Journal of Tropical Pediatrics, 2017, Vol 63, Issue 3, p167
- ISSN
0142-6338
- Publication type
journal article
- DOI
10.1093/tropej/fmw066