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- Title
Metriculator: quality assessment for mass spectrometry-based proteomics.
- Authors
Taylor, Ryan M.; Dance, Jamison; Taylor, Russ J.; Prince, John T.
- Abstract
Summary: Quality control in mass spectrometry-based proteomics remains subjective, labor-intensive and inconsistent between laboratories. We introduce Metriculator, a software designed to facilitate long-term storage of extensive performance metrics as introduced by NIST in 2010. Metriculator features a web interface that generates interactive comparison plots for contextual understanding of metric values and an automated metric generation toolkit. The comparison plots are designed for at-a-glance determination of outliers and trends in the datasets, together with relevant statistical comparisons. Easy-to-use quantitative comparisons and a framework for integration plugins will encourage a culture of quality assurance within the proteomics community.Availability and Implementation: Available under the MIT license at http://github.com/princelab/metriculator.Contact: jtprince@chem.byu.edu
- Subjects
MASS spectrometry; PROTEOMICS; QUALITY control; QUALITY assurance; COMPARATIVE studies; BIOINFORMATICS
- Publication
Bioinformatics, 2013, Vol 29, Issue 22, p2948
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btt510