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- Title
Effectiveness of additional topical antibiotics for recurrent or refractory exit-site infection: a case series.
- Authors
Asai, Nao; Suzuki, Yasuhiro; Asai, Akimasa; Kinashi, Hiroshi; Kamiya, Keisuke; Hagita, Junichiro; Matsuoka, Naoya; Kawamura, Suzuka; Fukui, Sosuke; Kim, Hangsoo; Yamaguchi, Makoto; Katsuno, Takayuki; Mizuno, Masashi; Ishimoto, Takuji; Ito, Yasuhiko
- Abstract
Background: Japanese peritoneal dialysis (PD) guidelines do not suggest applying mupirocin/gentamicin ointment to the exit sites of PD patients to prevent exit-site infection (ESI). The guidelines do not mention topical antimicrobials as a treatment for ESI. Methods: We retrospectively investigated the additional use of topical antibiotic ointments on patients receiving oral or intravenous antibiotics for recurrent and/or refractory ESI at Aichi Medical University and Nagoya University Hospitals between 2017 and 2022. Results: A total of 13 patients (11 men, 2 women) were included in this study. Median age was 69.0 years, median duration of PD was 26.0 months, two patients had diabetes as a complication, and ESI incidence was 2.7 episodes per patient-year. Systemic antibacterial treatment had been administered for a median of 27.0 days before application therapy. Mupirocin was used in eight cases and gentamicin in five cases, with complete resolution in all cases. No adverse effects such as skin symptoms, antibiotic resistance, or non-tuberculous mycobacterial infections were observed. Cases were divided into two groups based on the duration of topical antibiotic use: short-term group < 90 days and long-term group ≥ 90 days. All patients in both groups achieved complete resolution, with no significant differences in time to resolution, number of recurrent ESIs, or occurrence of ESIs after discontinuation of application therapy. Conclusion: Additional use of topical antibiotic for recurrent and/or refractory ESI appears safe and effective. This study suggests that future randomized controlled trials are warranted.
- Subjects
ANTIBIOTICS; CUTANEOUS therapeutics; PERITONEAL dialysis; NEPHROSCLEROSIS; PATIENT safety; CATHETER-related infections; OINTMENTS; TREATMENT effectiveness; RETROSPECTIVE studies; HOST-bacteria relationships; METHICILLIN-resistant staphylococcus aureus; ORAL drug administration; TREATMENT duration; DESCRIPTIVE statistics; CHRONIC kidney failure; POLYCYSTIC kidney disease; ANTI-infective agents; VANCOMYCIN; INTRAVENOUS therapy; MEDICAL records; ACQUISITION of data; X-rays; MUPIROCIN; DISEASE relapse; CASE studies
- Publication
Renal Replacement Therapy, 2024, Vol 10, Issue 1, p1
- ISSN
2059-1381
- Publication type
Article
- DOI
10.1186/s41100-024-00547-x