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- Title
Effect of Crude Extracts from the Bark and Leaf of Cinnamomum Zeylanicum (Cinnamon) on the Levels of Glucose, Triglycerides and Fatty Live.
- Authors
de Almeida Costa, Jaciane; Ribeiro Clark, Arthur Tenório; Nascimento Domingues da Silva, Carlos Henrique; Roberto da Silva, Givanildo; Lira Soares, Luiz Alberto; Assunção Ferreira, Magda Rhayanny; Pereira Barbosa, Miriam; Gomes Carneiro, Mariane; Lyra de Freitas, Manuela Figueiroa
- Abstract
Introduction: considering the benefits of cinnamon consumption, the objective was to evaluate the action of crude extracts of the leaf and bark of the cinnamon stem (Cinnamomum zeylanicum) on biochemical parameters and histological, morphometric, and stereological aspects of the liver of obese rats. Methods: thirty male Wistar rats were divided into two groups: normonourished and obese. The normonourished received standard diet and the obese group received hypercaloric diet, from the 21st to the 120th day of life. After 99 days of diet intake, the rats were divided into six subgroups and treated with extracts by gavage for 21 days at a dose of 200 mg/kg. At the end of the treatment, the animals were euthanized, the blood collected for biochemical measurements and the liver tissue for histological, morphometric, and stereological analysis. Results: cinnamon extracts improved the plasma triglyceride profile, reduced blood glucose levels, reduced AST levels, and decreased the volume of the middle lobe of the liver of obese rats. In the histological analysis, it was observed that the extracts acted by reducing the hepatic steatosis. Conclusion: the results found demonstrate that the dose and time of use of cinnamon extract can reverse some adverse effects of an obesogenic diet and, consequently, the development of non-alcoholic fatty liver disease (NAFLD). However, these findings should be continued with complementary studies, such as the isolation of specific substances from the extracts, diversified doses, and longer usage times for better use of raw cinnamon extracts in the prevention and development of NAFLD.
- Subjects
CINNAMON tree; NON-alcoholic fatty liver disease; CINNAMON; NUTRITIONALLY induced diseases; FATTY liver; RAW foods; EPICATECHIN
- Publication
Journal of Morphological Sciences, 2023, Vol 40, p151
- ISSN
2177-0298
- Publication type
Article
- DOI
10.51929/jms.40.151.2023