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- Title
Seeds and Soil: Unraveling the Role of Local Tumor Stroma in Distant Metastasis.
- Authors
Duda, Dan G.; Ancukiewicz, Marek; Isakoff, Steven J.; Krop, Ian E.; Jain, Rakesh K.
- Abstract
The article discusses local tumor stroma's role in the development of distant metastasis, which is blamed as the major cause of mortality among cancer patients. Topics discussed include the discovery of gene signatures that shows cancer cells' intrinsic properties and its influence on distant metastasis and the discovery of Rohan and colleagues on the association between Tumor MicroEnvironment for Metastasis (TMEM) and the risk of metastatic recurrence.
- Subjects
CANCER cell proliferation; METASTASIS; ETIOLOGY of cancer; TUMOR growth; CANCER research
- Publication
JNCI: Journal of the National Cancer Institute, 2014, Vol 106, Issue 8, p1
- ISSN
0027-8874
- Publication type
Editorial
- DOI
10.1093/jnci/dju187