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- Title
Dual-Time-Point 18F-FDG PET/CT in Infective Endocarditis: Impact of Delayed Imaging in the Definitive Diagnosis of Endocarditis.
- Authors
Padilla Bermejo, Amanda; Pena Pardo, Francisco José; Noriega-Álvarez, Edel; Amo-Salas, Mariano; Sicilia Pozo, María de las Nieves; García Vicente, Ana María; Poblete-García, Víctor Manuel
- Abstract
Infective endocarditis (IE) is a major public health condition due to the associated high morbidity and mortality. Our objective was to evaluate the utility of dual-time 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) imaging in the diagnosis of active IE in patients with suspected native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE). For this purpose, a retrospective study was carried out, including patients suspicious of NVE or PVE who underwent a dual-time-point 18F-FDG PET/CT. A final diagnosis was established by the Endocarditis Team after patient follow-up using all the available findings. Sixty-nine patients were assessed. A final diagnosis of NVE was established in 3 patients of the 34 by 18F-FDG PET/CT and in the case of PVE was established in 20 patients of the 35. A statistically significant association was found when evaluating the association between PET diagnosis at early acquisition and final diagnosis of IE (χ2 = 30.198, p < 0.001) and PET diagnosis at delayed acquisition for final diagnosis of IE (χ2 = 9.412, p = 0.002). Delayed PET/CT imaging determined the IE diagnosis in 16/58 of the studies. In conclusion, delayed 18F-FDG PET/CT imaging seems to be useful in improving the definitive diagnosis of IE.
- Subjects
INFECTIVE endocarditis; POSITRON emission tomography; ENDOCARDITIS; FLUORODEOXYGLUCOSE F18; DELAYED diagnosis; DIAGNOSIS
- Publication
Biomedicines, 2024, Vol 12, Issue 4, p861
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines12040861