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- Title
Hydroxybenzoyl Chlorides in the Synthesis of Conjugates with Biologically Active Dipeptides.
- Authors
Brel, A. K.; Lisina, S. V.; Budaeva, Yu. N.
- Abstract
Conjugates of hydroxy- and acetoxybenzoic acids with dipeptides based on 4-aminobutanoic acid and glycine were synthesized through hydroxy(acetoxy)benzoyl chlorides and 4-[hydroxy(acetoxy)benzoyl-amino]butanoyl chlorides as intermediate products. Acyl chlorides were prepared by treatment of the corre-sponding acids with oxalyl chloride in the presence of dimethylformamide at a ratio of 1:1.1:0.07 in boiling benzene. The target N-[hydroxy(acetoxy)benzoyl] derivatives of dipeptides were obtained with high yields, and no further purification of the products was necessary. The synthesized compounds were evaluated as potential neuroprotective agents.
- Subjects
DIPEPTIDES; OXALYL chloride; BENZOYL chloride; GLYCINE; BENZOYL compounds; CHLORIDES; ACYL chlorides; CHEMICAL synthesis
- Publication
Russian Journal of Organic Chemistry, 2021, Vol 57, Issue 4, p540
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428021040060