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- Title
Synthesis and anti-influenza activity of 2-cyanoethoxy and 2-(1 H-tetrazol-5-yl)ethoxy derivatives of dammarane-type triterpenoids.
- Authors
Zorina, A.; Kaledina, A.; Motsepuro, I.; Anokhina, V.; Marchenko, S.; Selivanov, S.; Zarubaev, V.; Trifonov, R.
- Abstract
A series of 3-(2-1 Н-tetrazol-5-ylethoxy- and 2-1 Н-tetrazol-5-ylethoxyimino) derivatives of dammarane triterpenoids was synthesized by azidation of 3-(2-cyanoethoxy- and 2-cyanoethoxyimino)-dammaranes. The anti-influenza activity of the prepared tetrazolyldammaranes and intermediate compounds against influenza virus А H1N1 was tested. A considerable antiviral activity was observed for 20(S)-3-(2-1 Н-tetrazol-5-ylethoxyimino)-25,26,27-trinor-20,24-olidedammarane (SI 26).
- Subjects
CHEMICAL synthesis; DAMMARANES; TRITERPENOIDS; AZIDATION; ANTIVIRAL agent synthesis
- Publication
Russian Journal of Organic Chemistry, 2017, Vol 53, Issue 11, p1710
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428017110185