We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review.
- Authors
Dănilă, Alexandra-Ioana; Ghenciu, Laura Andreea; Stoicescu, Emil Robert; Bolintineanu, Sorin Lucian; Iacob, Roxana; Săndesc, Mihai-Alexandru; Faur, Alexandra Corina
- Abstract
The escalating global prevalence of diabetes mellitus (DM) over the past two decades has led to a persistent high incidence of diabetic retinopathy (DR), necessitating screening for early symptoms and proper treatment. Effective management of DR aims to decrease vision impairment by controlling modifiable risk factors including hypertension, obesity, and dyslipidemia. Moreover, systemic medications and plant-based therapy show promise in advancing DR treatment. One of the key mechanisms related to DR pathogenesis is the polyol pathway, through which aldose reductase (AR) catalyzes the conversion of glucose to sorbitol within various tissues, including the retina, lens, ciliary body and iris. Elevated glucose levels activate AR, leading to osmotic stress, advanced glycation end-product formation, and oxidative damage. This further implies chronic inflammation, vascular permeability, and angiogenesis. Our comprehensive narrative review describes the therapeutic potential of aldose reductase inhibitors in treating DR, where both synthetic and natural inhibitors have been studied in recent decades. Our synthesis aims to guide future research and clinical interventions in DR management.
- Subjects
DIABETIC retinopathy; ALDOSE reductase; VISION disorders; CILIARY body; HYPERTENSION risk factors; REDUCTASE inhibitors
- Publication
Biomedicines, 2024, Vol 12, Issue 4, p747
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines12040747