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- Title
Synthesis of Novel Hybrids Containing 1,2,3-Triazole-Linked Tetrazole Moieties, Evaluation of Anticancer Activity and Molecular Docking Studies.
- Authors
Jarupula, V.; E, Praveen Kumar; Bujji, S.; Shivarathri, P.; Neeradi, S.; Morthad, M.; Reddy, Kotha Laxma
- Abstract
Novel hybrids containing 1,2,3-triazole linked tetrazole derivatives were synthesized and characterized by various analytical techniques like 1H, 13C NMR and LC-MS. All the compounds were screened for their anticancer activity against two cancer cell lines A-549 and MCF-7 by using MTT assay and doxorubicin as standard drug. Molecular docking studies were performed on ERK2 using Auto dock Vina of PyRx tool. The binding energies and interactions acquired from docking results of compounds supported the experimental data.
- Subjects
TETRAZOLES; MOLECULAR docking; ANTINEOPLASTIC agents; MOIETIES (Chemistry); DRUG standards; BINDING energy
- Publication
Russian Journal of General Chemistry, 2023, Vol 93, pS849
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363223170012