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- Title
Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates.
- Authors
Gorbunova, I. A.; Sharavyeva, Yu. O.; Makhmudov, R. R.; Shipilovskikh, D. A.; Shadrin, V. M.; Pulina, N. A.; Shipilovskikh, S. A.
- Abstract
A method was proposed for the synthesis of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates containing a nitrile substituent in the thiophene ring by reacting the corresponding 3-thienylimino-3H-furan-2-ones with primary alcohols. The antinociceptive activity and acute toxicity of the obtained compounds were investigated. It was found that the substituted esters have pronounced antinociceptive activity and low toxicity. According to the classification of toxicity of drugs, the obtained substituted of 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates belong to the V class toxicity.
- Subjects
DRUG toxicity; ESTERS; ALCOHOL; THIOPHENES
- Publication
Russian Journal of General Chemistry, 2022, Vol 92, Issue 10, p1899
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363222100048