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- Title
When gluttony strikes: how high‐fat diet impairs hepatic Ca<sup>2+</sup> signalling.
- Authors
Merrild, Christoffer; Johansen, Valdemar Brimnes Ingemann
- Abstract
Looking ahead In summary, the authors demonstrated that HFD hepatocytes required a 10-fold higher NA concentration to obtain the half-maximal effective concentration of NA-stimulated cytosolic Ca SP 2+ sp signalling compared to LFD hepatocytes (Fig. Keywords: calcium imaging; calcium signalling; high fat diet; in vivo; metabolism; NAFLD; NASH; obesity EN calcium imaging calcium signalling high fat diet in vivo metabolism NAFLD NASH obesity 2245 2247 3 06/19/23 20230615 NES 230615 Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of metabolic syndrome (Lazarus et al., [5]), and end-stage NAFLD, an inflammatory disease, is known as non-alcoholic steatohepatitis (NASH). The frequency of cytosolic calcium oscillations was lower in primary HFD hepatocytes compared to LFD hepatocytes, and the latter had significantly fewer calcium misfiring spikes in the oscillatory signalling train, although the shape of each spike, i.e. full width at half maximum, was unchanged (Brumer et al., [2]).
- Subjects
HIGH-fat diet; FATTY liver; LEPTIN; CALCIUM ions
- Publication
Journal of Physiology, 2023, Vol 601, Issue 12, p2245
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP284742