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- Title
Iodine-Catalyzed Formation of Amide Bond: Efficient Strategy for the Synthesis of Aromatic Primary Amides.
- Authors
Xie, ZENgyang; ChEN, Ruijiao; Du, Zhongyu; Kong, Lingdong; Li, ZhENquan; Li, Zhaolou; Wang, Ning; Liu, Jun
- Abstract
A practical and efficient methodology for the synthesis of aromatic primary amides by reaction of benzylic alcohols and aqueous ammonia in the presence of an I2/TBHP system in acetonitrile was developed. This oxidative amidation proceeded smoothly at ambient temperature and tolerated a variety of functional groups. A wide range of aromatic primary amides were obtained in moderate to high yields. Preliminary kinetic studies and a possible mechanism of the oxidative amidation reaction were also discussed.
- Subjects
AMIDE synthesis; IODINE; CATALYSIS
- Publication
Asian Journal of Organic Chemistry, 2017, Vol 6, Issue 2, p157
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201600532