We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Next Generation Sequencing As an Aid to Diagnosis and Treatment of an Unusual Pediatric Brain Cancer.
- Authors
Glod, John; Mihae Song; Sharma, Archana; Tyagi, Rachana; Rhodes, Roy H.; Weissmann, David J.; Roychowdhury, Sudipta; Khan, Atif; Kane, Michael P.; Hirshfield, Kim; Ganesan, Shridar; DiPaola, Robert S.; Rodriguez-Rodriguez, Lorna
- Abstract
Classification of pediatric brain tumors with unusual histologic and clinical features may be a diagnostic challenge to the pathologist. We present a case of a 12-year-old girl with a primary intracranial tumor. The tumor classification was not certain initially, and the site of origin and clinical behavior were unusual. Genomic characterization of the tumor using a Clinical Laboratory Improvement Amendment (CLIA)-certified next-generation sequencing assay assisted in the diagnosis and translated into patient benefit, albeit transient. Our case argues that next generation sequencing may play a role in the pathological classification of pediatric brain cancers and guiding targeted therapy, supporting additional studies of genetically targeted therapeutics.
- Subjects
BRAIN tumors; BRAIN death in children; INTRACRANIAL arterial diseases; BRAIN cancer; COMPARATIVE genomic hybridization
- Publication
Journal of Personalized Medicine, 2014, Vol 4, Issue 3, p402
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm4030402