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- Title
The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring.
- Authors
Beck, Roy; Steffes, Michael; Xing, Dongyuan; Ruedy, Katrina; Mauras, Nelly; Wilson, Darrell M; Kollman, Craig
- Abstract
Beck R, Steffes M, Xing D, Ruedy K, Mauras N, Wilson DM, Kollman C, the Diabetes Research in Children Network (DirecNet) Study Group. The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring. Objectives: To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5-anhydroglucitrol (1,5-AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes. Methods: In total, 26 subjects of age 4-17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21). Results: Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5-AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM-measured mean glucose (absolute r value = 0.50-0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/dL (0.50-0.60). Conclusion: Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5-AG) had a similar correlation with mean glucose and hyperglycemic AUC-180. 1,5-AG did not correlate with hyperglycemic AUC-180 better than did HbA1c.
- Subjects
HYPERGLYCEMIA; AMMONIA; ANALYSIS of variance; DIABETES; FRUCTOSE; GLUCOSE; GLYCOSYLATED hemoglobin; METABOLIC regulation; MONOSACCHARIDES; PATIENT monitoring; PEDIATRICS; PROTEINS; DATA analysis; ALBUMINS; DIAGNOSIS
- Publication
Pediatric Diabetes, 2011, Vol 12, Issue 8, p690
- ISSN
1399-543X
- Publication type
Article
- DOI
10.1111/j.1399-5448.2011.00764.x