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- Title
ABO blood group influences a candidate's likelihood of receiving an HLA zero antigen mismatch kidney.
- Authors
Bryan, Christopher F.; Cherikh, Wida S.; Cheng, Yulin; Aeder, Mark I.; Muruve, Nicolas A.; Nelson, Paul W.; Shield III, Charles F.; Warady, Bradley A.; Winklhofer, Franz T.
- Abstract
Bryan CF, Cherikh WS, Cheng Y, Aeder MI, Muruve NA, Nelson PW, Shield III CF, Warady BA, Winklhofer FT. ABO blood group influences a candidate's likelihood of receiving an HLA zero antigen mismatch kidney. Clin Transplant 2004: 18 (Suppl. 12): 55–60. © Blackwell Munksgaard, 2004 National sharing of HLA zero-mismatched kidneys has improved long-term graft survival. The distribution of those HLA-matched kidneys by ABO blood group, however, has not been examined. Utilizing the UNOS/OPTN (United Network for Organ Sharing/Organ Procurement Transplantation Network) database, we analysed 112 971 kidney waiting list registrations added during 6/3/95–31/12/00, and 8162 HLA zero-mismatched (0 mm) primary kidney transplants in the USA during 1/1/88–31/3/02. We also analyzed A isoagglutinin titer histories for 87 blood group B end stage renal disease (ESRD) patients for whom at least 1 yr of testing was done. Blood group A patients received 40.1% of the HLA-0 mm kidneys while having a 26.5% representation on the national waiting list. Blood group B patients comprised 17.4% of the waiting list, but received only 10.4% of the HLA-0 mm kidneys. Most (89.6%) blood group B patients awaiting kidney transplantation have low levels of A isoagglutinins, making them eligible to receive a blood group A2 kidney transplant. The national HLA-0 mm kidney allocation sharing system's imbalance by ABO blood group could be partially resolved in the future by allocating HLA-0 mm blood group A2 kidneys to B patients.
- Subjects
BLOOD groups; HLA histocompatibility antigens; KIDNEY transplantation; TRANSPLANTATION of organs, tissues, etc.; HOMOGRAFTS
- Publication
Clinical Transplantation, 2004, Vol 18, p55
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1111/j.1399-0012.2004.00219.x