We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng.
- Authors
Sun, Wen-Jie; Zhu, Hong-Tao; Zhang, Tian-Yuan; Zhang, Meng-Yue; Wang, Dong; Yang, Chong-Ren; Zhang, Yi-Xuan; Zhang, Ying-Jun
- Abstract
Abstract: Panax notoginseng (Araliaceae) is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of China. Two new alkaloids, rigidiusculamide E (1) and [-(α-oxyisohexanoyl-N-methyl-leucyl)2-] (2), together with two known ones, (−)-oxysporidinone (3) and (−)-4,6′-anhydrooxysporidinone (4) were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082, an endophytic fungus obtained from the healthy root of P. notoginseng. Their structures were determined on the basis of extensive spectroscopic analyses. Compounds 1-4 were tested for their inhibitory effects against NO production on Murine macrophage cell line, and the new compound 2 showed significant inhibitory activity on NO production with the IC50 value of 18.10 ± 0.16 μM.Graphical Abstract: <graphic></graphic>
- Subjects
YUNNAN Sheng (China); ALKALOIDS; FUSARIUM; ENDOPHYTES; ARALIACEAE
- Publication
Natural Products & Bioprospecting, 2018, Vol 8, Issue 5, p391
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-018-0171-0