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- Title
An 11-Year Follow-up Study of Neonatal-Onset, Bath-Induced Alternating Hemiplegia of Childhood in Twins.
- Authors
Incorpora, Gemma; Pavone, Piero; Polizzi, Agata; Cocuzza, Mariadonatella; Privitera, Michael; Pavone, Lorenzo; Ruggieri, Martino
- Abstract
The authors previously reported on the initial manifestations in a set of female twins, who presented soon after birth with bath-induced paroxysmal events each time they were immersed in a warm water bath. These episodes progressively ceased by the age of 36 months, replaced by paroxysmal episodes of alternating hemiplegia unrelated to water immersion. By age 4 years, the twins developed the classic features of alternating hemiplegia of childhood. Clinical outcomes at the age of 11 years are now reported. Standard and video-electroencephalograms showed a large, slow background activity followed by lower amplitude waves without focal abnormalities or other abnormal findings. This represents the first report on (a) alternating hemiplegia of childhood started with bath-induced paroxysmal episodes; (b) this condition in monozygotic twins; and (c) an 11-year follow-up study in which the twins continue to experience episodes of alternating hemiplegia in the setting of baseline cognitive impairment without epileptic episodes.
- Subjects
HEMIPLEGIA; DISEASES in twins; FOLLOW-up studies (Medicine); PAROXYSMAL hemoglobinuria; HEALTH outcome assessment; ELECTROENCEPHALOGRAPHY; DIAGNOSIS
- Publication
Journal of Child Neurology, 2012, Vol 27, Issue 5, p657
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073811436249