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- Title
Juvenile Onset Central Nervous System Folate Deficiency and Rheumatoid Arthritis.
- Authors
Koenig, Mary Kay; Perez, Maria; Rothenberg, Sheldon; Butler, Ian J.
- Abstract
Isolated cerebral folate deficiency was detected in a 13-year-old girl with cognitive and motor difficulties and juvenile rheumatoid arthritis. Her serum contains autoantibodies that block membrane-bound folate receptors that are on the choroid plexus and diminish the uptake of folate into the spinal fluid. Whereas her serum folate exceeded 21 ng/mL, her spinal fluid contained 3.2 ng/mL of 5-rnethyltetrahydrofolate as a consequence of the autoantibodies diminishing the uptake of this folate.
- Subjects
VITAMIN B deficiency; VITAMIN deficiency; JUVENILE idiopathic arthritis; RHEUMATISM in children; AUTOANTIBODIES; PEDIATRIC neurology
- Publication
Journal of Child Neurology, 2008, Vol 23, Issue 1, p106
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073807307986