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- Title
Cytomegalovirus disease in adult marrow transplant recipients receiving ganciclovir prophylaxis: a retrospective study.
- Authors
Maltazou, H; Whimbey, E; Abi-Said, D; Przepiorka, D; Champlain, R; Goodrich, J M
- Abstract
In a retrospective study, we compared the incidence and risk of mortality associated with CMV disease in adult allogeneic BMT and PBSC recipients who received ganciclovir prophylaxis three-times-per-week (78 patients) vs five-times-per-week (137 patients). Active CMV infection occurred in 28 (41%) and 26 (21%) in the three- vs five-times-per-week groups, respectively (P < 0.005). cmv disease developed in 11 (16%) and five (4%) patients who received ganciclovir prophylaxis in the three-times-per-week vs five-times-per-week groups (P < 0.004). the cmv-attributable mortality rate was 1.5% and 12% in the five- vsthree-times-per-week groups, respectively (P < 0.003). risk factors for cmv disease, significant at the P < 0.05 level in the multivariate analysis, were ganciclovir prophylaxis at three-times-per-week, receiving a t cell-depleted (tcd) marrow, and tacrolimus as prophylaxis for gvhd. these data suggest that ganciclovir five-times-per-week significantly reduced the incidence and mortality of cmv disease in allogeneic bmt and pbsc recipients. however, ganciclovir five-times-per-week was less effective for the prevention of cmv disease in patients receiving tcd marrow or tacrolimus.
- Subjects
CYTOMEGALOVIRUS diseases; BONE marrow transplantation; GANCICLOVIR
- Publication
Bone Marrow Transplantation, 1999, Vol 24, Issue 6, p665
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1701948