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- Title
Primary manifestation of HIV-related Burkitt lymphoma in the oral and maxillofacial regions.
- Authors
Silva Filho, Nilton José da; Cardoso, Diovana de Melo; Kayahara, Giseli Mitsuy; Xavier-Júnior, José Cândido Caldeira; Cortopassi, Gabriel Macedo; Fonseca, Felipe Paiva; Miyahara, Glauco Issamu; Bernabé, Daniel Galera; Valente, Vitor Bonetti
- Abstract
Burkitt lymphoma (BL) is a subtype of non-Hodgkin lymphoma. It is strongly associated with HIV infection and has a highly aggressive clinical course. The involvement of the maxillofacial region in BL has rarely been reported. A 36-year-old woman with HIV-positive status had painless bilateral swelling of the oral mucosa and middle and lower thirds of the face. Microscopic analysis of the oral lesion revealed an atypical lymphoid infiltrate with a starry sky pattern. The lymphoid cells expressed cluster of differentiation 20, cluster of differentiation 10, B-cell lymphoma 6, and c-Myc; the Ki-67 proliferative index was high. The tumor cells were positive for Epstein-Barr virus. These results led to the diagnosis of HIV-related BL. BL and other immunodeficiency-related lymphoproliferative malignancies may affect the oral and maxillofacial regions and should be included in the differential diagnosis of rapidly expanding swelling in young patients.
- Subjects
DIAGNOSIS of HIV infections; MOUTH; MOUTH tumors; DIFFERENTIAL diagnosis; HIV-positive persons; EDEMA; EPSTEIN-Barr virus diseases; CELL lines; LYMPHOID tissue; LYMPHOPROLIFERATIVE disorders; B cell lymphoma
- Publication
Journal of the American Dental Association (JADA), 2024, Vol 155, Issue 4, p344
- ISSN
0002-8177
- Publication type
Article
- DOI
10.1016/j.adaj.2023.11.012