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- Title
A structural study of lamellar phases formed by nucleoside-functionalized lipids.
- Authors
Berti, D.; Fratini, E.; Dante, S.; Hauss, T.; Baglioni, P.
- Abstract
We report a neutron-scattering investigation of lamellar phases formed by novel phospholipids bearing nucleosides at the polar-head-group region. These nucleolipids can interact through stacking and H-bond interactions, following a pattern that resembles base-base coupling in natural nucleic acids (DNA, RNA), i.e. they have similar recognition properties. Bilayer stacks formed of DPP-adenosine, DPP-uridine and their 1:1 mixture were investigated after equilibration in a 98% relative humidity atmosphere. The DPP-adenosine spectrum can be accounted for (in analogy to DPPC) by a lamellar phase with a smectic period of about 60 Å. DPP-uridine displays a not so straightforward behavior that we have tentatively ascribed to the coexistence of lamellae with different smectic periods. In the 1:1 mixture the lamellar mesophase of DPP-uridine is retained, suggesting a specific interaction of the uridine polarhead group with the adenosine moiety of DPP-adenosine. It should be stressed that this behavior can be considered as an indication of the recognition process occurring at the polar-head-group region of the mixed phospholiponucleoside membrane.
- Subjects
PHOSPHOLIPIDS; NUCLEOSIDES; NEUTRON scattering
- Publication
Applied Physics A: Materials Science & Processing, 2002, Vol 74, Issue 6, ps522
- ISSN
0947-8396
- Publication type
Article
- DOI
10.1007/s003390101116