We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cost-effectiveness analysis of lung cancer screening with low-dose computed tomography in an Iranian high-risk population.
- Authors
Esmaeili, Mansur Haji; Seyednejad, Farshad; Mahboub-Ahari, Alireza; Ameri, Hosein; Abdollahzad, Hadi; Safaei, Naser; Alinezhad, Farbod; Yousefi, Mahmood
- Abstract
Objective: The results of recent studies have shown that using low-dose computed tomography (LDCT) for screening of lung cancer (LC) improves cancer outcomes. The objective of the current study was to evaluate the cost-effectiveness of LDCT in an Iranian high-risk population. Methods: A Markov cohort simulation model with four health states was used to evaluate the cost-effectiveness of LDCT from a healthcare system perspective in the people aged 55–74 who smoked 25 or more cigarettes per day for 10–30 years. Cost data were collected, reviewing 324 medical records of patients with LC, and utilities and transition probabilities were extracted from the literature. The Monte Carlo simulation method was applied to run the model. Probabilistic sensitivity analysis and one-way analysis were also performed. Results: LC screening in comparison to a no-screening strategy was costly and effective. The incremental cost-effectiveness ratio of screening versus no-screening was IRR (Iranian rials) 98,515,014.04 which falls below the Iranian threshold of three times GDP (gross domestic product) per capita. One-way and probabilistic sensitivity analyses demonstrated that the results of the economic analysis were robust to variations in the key inputs for both. Conclusions: Using LDCT for screening of LC patients in a high-risk population is a cost-effective strategy.
- Subjects
IRAN; COMPUTER simulation; ACQUISITION of data methodology; ONE-way analysis of variance; LUNG tumors; EARLY detection of cancer; MEDICAL care costs; CANCER patients; COMPARATIVE studies; COST effectiveness; MEDICAL records; DESCRIPTIVE statistics; COMPUTED tomography; SMOKING; LONGITUDINAL method; DISEASE risk factors
- Publication
Journal of Medical Screening, 2021, Vol 28, Issue 4, p494
- ISSN
0969-1413
- Publication type
Article
- DOI
10.1177/09691413211018253