We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development and Characterization of Fast Dissolving Tablet of Diflunisal by Solid Dispersion Method.
- Authors
Tiwari, Reshu; Singh, Satya Prakash; Kushwaha, Poonam; Usmani, Shazia
- Abstract
Aim and Objective: Solubility is the important physicochemical factors which affect the absorption of drug and therapeutic effectiveness. The poor solubility of drug substance in water and low absorption in aqueous GIT fluid leads to insufficient bioavailability. The purpose of present research work is to increase the aqueous solubility and dissolution rate of poorly water soluble drug. Materials and Method: Solubility of diflunisal enhanced by solid dispersion (kneading method) method using beta cyclodextrin as a carrier (also act as taste masking agent). Fast dissolving tablet of diflunisal was prepared by direct compression method using crospovidone as a superdisintigrant from optimized solid dispersion complexes. Prepared tablets were evaluated for various parameters: weight variation, hardness, friability, modified dispersion time, disintegration test, drug content and drug release. Results and conclusion: From the results obtained it has been concluded that prepared tablets from formulation F3 which contain 5% crospovidone as a superdisintigrant showed high dissolution rate and good flow property than other tablet prepared from solid dispersion.
- Subjects
DRUG solubility; DIFLUNISAL; DRUG bioavailability
- Publication
Pharmaceutical Methods, 2015, Vol 6, Issue 2, p60
- ISSN
2229-4708
- Publication type
Article
- DOI
10.5530/phm.2015.6.8