We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Analytical Method Development and Validation of Quetiapine Fumarate in API and Dosage form by Using RP-HPLC.
- Authors
LINGAREDDYGARI, SIVA SANKER REDDY; RAVIKRINDHI, NAGESWARA RAO; NOOKALA, MADANA GOPAL; MUNEER, SHAIK; NAKKA, PRASAD
- Abstract
RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5µm column (4.6mm×200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 minute. The linearity of the drug concentration ranges from 20-400µg/mL. The detection and quantification limits were intended at 3.70µg/mL and 12.35µg/mL. The precision, accuracy, specificity, robustness and degradation studies were validated.
- Subjects
HIGH performance liquid chromatography; QUETIAPINE; RF values (Chromatography); ACETONITRILE; DETECTION limit
- Publication
Oriental Journal of Chemistry, 2023, Vol 39, Issue 4, p1040
- ISSN
0970-020X
- Publication type
Article
- DOI
10.13005/ojc/390430