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- Title
Papio spp. Colon microbiome and its link to obesity in pregnancy.
- Authors
Li, XuanJi; Rensing, Christopher; Taylor, William L.; Costelle, Caitlin; Brejnrod, Asker Daniel; Ferry, Robert J.; Higgins, Paul B.; Folli, Franco; Kottapalli, Kameswara Rao; Hubbard, Gene B.; Dick, Edward J.; Yooseph, Shibu; Nelson, Karen E.; Schlabritz‐Loutsevitch, Natalia
- Abstract
Introduction: Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. Material and methods: Banked tissues were collected under sterile conditions during necropsy, from three non‐obese (nOb) and four obese (Ob) near‐term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test. Results: Three families predominated in both the nOb and Ob colonic microbiome: Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups. Conclusion: Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.
- Subjects
COLON microbiology; GUT microbiome; PREGNANCY in animals; OBESITY in animals; BABOONS; PRIMATE reproduction
- Publication
Journal of Medical Primatology, 2018, Vol 47, Issue 6, p393
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/jmp.12366