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- Title
Globin Chain Synthesis in Sickle Cell Trait Under Conditions of Folate Antagonism.
- Authors
Honig, George R.; Mason, George; Vida, Loyda N.
- Abstract
Folic acid deficiency has been reported to produce a substantial change in the ratio of hemoglobin S to hemoglobin A in the blood of individuals having sickle cell trait. Synthesis of the specific β-chains of these hemoglobins was studied before and after folate antagonism was produced by methotrexate administration. Incorporation of L-leucine-14C into β0 and βSby bone marrow cells was unchanged as a result of the treatment with methotrexate, indicating that synthesis of these globin chains was not selectively affected by the drug. Copyright © 1974 S. Karger AG, Basel
- Publication
Acta Haematologica, 1974, Vol 51, Issue 4, p236
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000208299