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- Title
Detection of the sign of defocus by the retina and its implication for myopia.
- Authors
Goethals, Sarah
- Abstract
To reduce myopia progression and mitigate its impact, it is necessary to slow down eye growth. Previous studies have shown that the retina is able to detect if the visual image, transformed by the eye optics, is focused in front or behind the retina, and subsequently modulates eye growth. However, it is not clear how it can achieve such a feat. We do not know what feature the retina extracts from the visual scene to detect if there is a positive (hyperopic) or negative (myopic) defocus. In this work, we aimed at understanding how the mouse retina can compute the sign of defocus from the visual input it receives. To investigate that question, we separated the respective contributions of the eye optics and of retinal processing by performing in vitro recordings of the isolated mouse retinas with multi‐electrode arrays while presenting natural images transformed by the simulated optics of the mouse eye for different values of defocus, simulating images focused in front of behind the retina. Our preliminary results show that this approach can be a promising method to understand how the retina detects whether the image is focused in front or behind the retina and can provide a mechanistic explanation for several results about myopia control solutions.
- Subjects
RETINA; RETINAL injuries; MYOPIA
- Publication
Acta Ophthalmologica (1755375X), 2024, Vol 102, pN.PAG
- ISSN
1755-375X
- Publication type
Abstract
- DOI
10.1111/aos.16375