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- Title
Biological Activity Investigation of Phytocomponents in Mangosteen (Garcinia mangostana L.): In Silico Study.
- Authors
Muhammad Ansori, Arif Nur; Kuncoroningrat Susilo, Raden Joko; Hayaza, Suhailah
- Abstract
Indonesia has abundant medicinal plants, which have been historically used by the population in treating diseases for generations. Traditional Indonesian medicine and the medicinal plants used could lead to the discovery of novel drugs. The mangosteen or Garcinia mangostana L. is a well-known medicinal plant that has been used to treat various diseases worldwide. The pharmacological activities and phytochemical composition of the whole plant of mangosteen have been investigated and identified by scientists in recent decades. Therefore, this study aims to generate the prediction of the biological activity of phytocompotents in mangosteen. In this study, we extracted 18 phyocomponents of mangosteen from PubChem, an open chemistry database at the National Institutes of Health (NIH), USA. Then, we predicted the pharmacokinetic properties and druglike nature of the phytocomponents using the SwissADME web server, Swiss Institute of Bioinformatics, Swiss. Furthermore, PASS (Prediction of Activity Spectra for Substances) web resource has been employed as a strong potential tool to predict the biological activity. In summary, we revealed the biological activity of 18 phytocomponents of the mangosteen. However, further trials, such as in vitro and in vivo evaluation, are needed to prove the validity of these findings.
- Subjects
INDONESIA; MANGOSTEEN; NATIONAL Institutes of Health (U.S.); MEDICINAL plants; INTERNET servers; TRADITIONAL medicine; CHEMICAL composition of plants; SCIENTISTS
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2021, Vol 15, Issue 1, p847
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v15i1.13522