We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Role of Mannose Receptor on HIV-1 Entry into Human Spermatozoa.
- Authors
Cardona-Maya, Wálter; López-Herrera, Albeiro; Velilla-Hernández, Paula; Rugeles, Maria T.; Cadavid, Ángela P.
- Abstract
In this opinion article we consider the possibility that human spermatozoa have receptors for human immunodeficiency virus-1 (HIV-1). It is clear that sperm cells have the potential for transmitting HIV-1, but the mechanisms responsible for spreading or the virus by this vector are not known. In contrast to the traditional HIV-1 target cells, spermatozoa do not express CD4 receptors or the CCR5/CXCR4 co-receptors. Recent evidence indicates that astrocytes, which also do not express these molecules, can be infected with HIV-1 through the mannose receptor. Furthermore, a 160-kDa sperm receptor that interacts with the HIV gp 120 has been described. Therefore, we hypothesize that the mannose receptor, of 165–175 kDa, is the receptor that HIV-1 uses to invade spermatozoa, which could lead to both vertical and horizontal transmission of HIV-1.
- Subjects
SPERMATOZOA; HIV; GERM cells; SEXUALLY transmitted diseases; CELLS
- Publication
American Journal of Reproductive Immunology, 2006, Vol 55, Issue 4, p241
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/j.1600-0897.2005.00340.x