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- Title
Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis.
- Authors
Bouton, Tara C.; de Vos, Margaretha; Ragan, Elizabeth J.; White, Laura F.; Van Zyl, Leonie; Theron, Danie; Horsburgh, C. Robert; Warren, Robin M.; Jacobson, Karen R.
- Abstract
South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.
- Subjects
SOUTH Africa; RIFAMPIN; COHORT analysis; TUBERCULOSIS; RETROSPECTIVE studies; DRUG resistance; OTOTOXICITY; SPINAL tuberculosis
- Publication
PLoS ONE, 2019, Vol 14, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0223308