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- Title
Buena VISTA: a promising outlook on targeting immune checkpoint regulators to combat sepsis.
- Authors
Mott, Madeline D; Trusiano, Briana; Allen, Irving Coy
- Abstract
The article discusses the role of immune checkpoint regulators, specifically VISTA, in the development and pathogenesis of sepsis. Sepsis is a condition caused by the host organism's reaction to an infection, and an unbalanced inflammatory response is believed to be a causative factor. The authors examine the role of VISTA in regulating the population and proliferation of γδ T cells, which play a critical role in sepsis and tissue damage. While VISTA does appear to have an impact on γδ T cell populations, the authors suggest that other factors may also regulate these cells. The findings suggest that targeting immune checkpoint regulators like VISTA may have potential therapeutic benefits in preventing sepsis.
- Subjects
IMMUNE checkpoint proteins; REGULATORY T cells; T cell receptors; SEPSIS; SEPTIC shock
- Publication
Journal of Leukocyte Biology, 2024, Vol 115, Issue 6, p1002
- ISSN
0741-5400
- Publication type
Article
- DOI
10.1093/jleuko/qiae080