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- Title
Assessment and prognostic value of serum uric acid and neuronspecific enolase on the efficacy of intravenous thrombolytic therapy in cerebral infarction.
- Authors
Yanjing Zang; Hongwei Zheng; Shuli Liu; Suyu Wang; Yan Shi
- Abstract
Assessment and prognostic value of serum uric acid (SUA) and neuron-specific enolase (NSE) on the efficacy of intravenous thrombolytic therapy in cerebral infarction. A retrospective analysis was performed on clinical data of 159 patients with acute cerebral infarction who received rt-PA intravenous thrombolytic therapy from 2015 to 2020 and patients with an mRS>2 points were assigned to the poor prognosis group and with mRS=2 to the good prognosis group. The receiver operating characteristic curve (ROC) was used to examine the prognostic value of SUA and NSE in intravenous thrombolytic therapy for acute cerebral infarction, and logistic regression analysis was utilized to elucidate the predictive features. SUA levels were adversely correlated with prognosis, whereas NSE was positively correlated with prognosis (r=0.465 and -0.501, P=0.000 and 0.000). The ROC curve showed that the predictive accuracy of SUA was 77.4% and of NSE was 71%. SUA=337.5 mmol/l and NSE=24.50 ng/ml are considered viable criteria to predict the curative effect and prognostic value of intravenous thrombolytic therapy for acute cerebral infarction. SUA and NSE demonstrate great potential to accurately predict the therapeutic effect and prognosis of intravenous thrombolytic therapy for acute cerebral infarction.
- Subjects
CEREBRAL infarction; THROMBOLYTIC therapy; INTRAVENOUS therapy; NATIONAL Institutes of Health (U.S.); PROGNOSIS; URIC acid; ENOLASE
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2023, p1325
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2023.36.4.SP.1325-1330.1