We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cell-cycle control and renal disease.
- Authors
Shankland, Stuart J.
- Abstract
The earliest investigators looking through primitive microscopes to study the pathology of renal disease recognized that an excess of cells was a central feature of many glomerular diseases particularly those with a prominent inflammatory component. Although it was initially thought that glomerular type regularity resulted primarily from invasion by circulating inflammatory cells, the much later recognition of the three separate intrinsic glomerular cell types and development of more sophisticated immunohistochemical techniques for identifying them made the people aware that much of the increased cellularity in glomerular disease resulted from proliferation of these intrinsic cell populations. This was followed by the discovery of specific cell-cycle proteins required for transition through the cell-cycle.
- Subjects
MICROSCOPY; PATHOLOGY; CYTOLOGY; GENETICS; CELL proliferation; CELL cycle
- Publication
Kidney International, 1997, Vol 52, Issue 2, p294
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1997.335