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- Title
Natriuretic peptide receptors A and B have different cellular distributions in rat kidney.
- Authors
Ritter, Detlef; Dean, Alan D.; Gluck, Stephen L.; Greenwald, James E.
- Abstract
The cellular distribution of guanylyl cyclase coupled natriuretic peptide receptors type A (GC-A) and type B (C/C-B) was examined by immunocytochemistry in normal rat kidney, and compared with the distribution of the vacuolar H+-ATPase. Staining for GC-A was found in glomeruli, thin limbs of Henle's loop, cortical collecting tubule, and inner medullary collecting duct: Staining for GC-B was found in glomeruli and the same nephron sections as GC-A, with the exception of the thin limbs. In the cortical collecting tubule, GC-A was found in both principal and intercalated cells: GC-B was restricted to the apical pole of a intercalated cells. In inner medullary collecting ducts cells, GC-A was located on the basal membrane, whereas GC-B was found in the apical pole. The different pattern of polarization of natriuretic peptide receptors in the inner medulla provides a plausible basis for the different physiologic effects of atrial natriuretic factor and C-type natriuretic peptide. The results also suggest the possibility that GC-B is involved in the regulation of bicarbonate transport in the cortical collecting tubule.
- Subjects
ATRIAL natriuretic peptides; PEPTIDE hormones; RATS; KIDNEY glomerulus; KIDNEY blood-vessels; IMMUNOCYTOCHEMISTRY
- Publication
Kidney International, 1995, Vol 48, Issue 6, p1758
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1995.474